Simple, Practical Ways to Assess the Protective Efficacy of a New Tuberculosis Vaccine
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چکیده
منابع مشابه
Simple, practical ways to assess the protective efficacy of a new tuberculosis vaccine.
There is strong evidence that tuberculin sensitivity cannot be used to evaluate the efficacy of different strains of bacille Calmette-Guérin (BCG). For identifying efficacious strains of BCG and evaluating candidates for new vaccines, the best method is a randomized trial. Simple trials in which newborns would be vaccinated with new and old vaccines in alternate years could demonstrate which va...
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New vaccines against tuberculosis are urgently required because of the impressive incidence of this disease worldwide and the highly variable protective efficacy of the current vaccine. The possibility of creating new live vaccines by the rational attenuation of strains from the Mycobacterium tuberculosis complex was investigated. Two auxotrophic mutants of M. tuberculosis and M. bovis BCG were...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2000
ISSN: 1537-6591,1058-4838
DOI: 10.1086/313870